Creatinine Clearance Rate (CCR) is a crucial indicator of kidney filtration function, often used to assess renal function and adjust drug dosages. This calculator uses the Cockcroft-Gault formula to estimate CCR.
Indicator Explanation
Creatinine Clearance Rate (CCR) refers to the kidney's ability to clear creatinine from the plasma per unit of time, serving as an important indicator of glomerular filtration function. Normal adult CCR is approximately 80-120 mL/min.
Decreased CCR may indicate impaired kidney function, commonly seen in chronic kidney disease and acute kidney injury. Clinically, it is often used for:
- Assessing kidney function status
- Guiding drug dosage adjustments for patients with renal insufficiency
- Monitoring the progression of kidney diseases
Calculation Formula
Cockcroft-Gault Formula
This calculator uses the Cockcroft-Gault formula to estimate creatinine clearance:
Male CCR (mL/min) = (140 - Age) × Weight (kg) × 1.23 / Serum Creatinine (μmol/L)
Female CCR (mL/min) = (140 - Age) × Weight (kg) × 1.04 / Serum Creatinine (μmol/L)
Where:
- Age: years
- Weight: kilograms (kg)
- Serum Creatinine: micromoles/liter (μmol/L)
Precautions:
- This formula is applicable to adults, not children.
- Results may be inaccurate for extremely obese or malnourished patients.
- Serum creatinine values should be stable.
Usage Guide
- Enter the patient's age, gender, weight, and serum creatinine value.
- Click the "Calculate CCR" button.
- The result will be displayed below.
Clinical Significance
CCR is an important indicator for assessing kidney function. When CCR decreases, drug dosages may need to be adjusted, especially for drugs primarily excreted by the kidneys. Persistent decrease in CCR suggests chronic kidney disease.
References
- Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
Disclaimer: This calculator is for reference only. Specific medical decisions should be made by professional medical personnel based on the patient's clinical condition.